Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Response to Vaccines in Patients with Immune-Mediated Inflammatory Diseases: A Narrative ReviewReview Published on 2022-02-152022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activating acute respiratory syndrome Affect antibody appear attenuate B-cell biologic Biologic therapy coronavirus CTLA-4 described dose Efficacy evaluated fusion protein healthy individuals IL-17 IL-6 immune response immune system Immune-mediated inflammatory disease Immune-mediated inflammatory diseases immunosuppressants immunosuppressive immunosuppressive drugs impair increased risk Infection Inflammatory bowel disease inhibitor inhibitors integrin Interleukins knowledge limit Live attenuated vaccine narrative Necrosis pathogenic Patient patients patients receiving treatment patients treated protective immune response protective response recommendation reduced replicate response responses review rheumatoid arthritis risk of infection Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine severe disease Therapies therapy TNF treat Treatment vaccination Vaccine vaccine response Vaccines [DOI] 10.3390/vaccines10020297 PMC 바로가기 [Article Type] Review
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal modelsSARS-CoV-2 RBD를 암호화하는 전기천공 DNA 백신 후보인 COVID-eVax는 동물 모델에서 보호 반응을 이끌어냅니다.Article Published on 2022-01-052022-09-11 Journal: Molecular therapy : the journal of the American So [Category] SARS, 변종, 진단, [키워드] animal model animal models anti-SARS-CoV-2 Antiviral antiviral immunity approved Brain caused cDNA clinical development COVID-19 COVID-19 pandemic COVID-19 vaccine Critical DNA DNA plasmid DNA vaccine domain effective vaccine Electroporation elicit European expressing ferret ferrets form hACE2 identify immunized K18-hACE2 transgenic mice lung Lungs monomeric Neutralizing antibody response neutralizing antibody responses profile protection. protective response Protein Pulmonary function RBD reduced robust Safe SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike secreted Skeletal muscle T cell T cell response the SARS-CoV-2 Trial Vaccine vaccine platform variants of concern Viral Viral antigen viral replication weight loss [DOI] 10.1016/j.ymthe.2021.09.011 PMC 바로가기 [Article Type] Article
Longitudinal dynamics of SARS-CoV-2-specific cellular and humoral immunity after natural infection or BNT162b2 vaccination자연 감염 또는 BNT162b2 백신 접종 후 SARS-CoV-2 특이적 세포 및 체액성 면역의 종적 역학Research Article Published on 2021-12-282022-09-12 Journal: PLoS Pathogens [Category] Coronavirus, SARS, 진단, [키워드] acute COVID-19 adaptive addition age and gender analysed anti-S anti-SARS-CoV-2 vaccination antibody BNT162b2 cellular Cellular and humoral responses cellular immunity cellular response characterized Clinical outcome comparable COVID-19 COVID-19 recovered patients declined description disease Early detection elicited emergency room healthy controls hospital humoral humoral immune response Humoral immunity Humoral response IFN-γ IL-2 immune response immune responses Immunity independent Infection information longitudinal longitudinal study Mild mild patients moderate natural infection neutralization capacity Neutralizing antibodies neutralizing antibody outcome Patient patients performed Post-infection Predictive Prognosis Prognostic value protective factor protective response provide public health recommendations robust SARS-CoV-2 SARS-COV-2 infection Seven severe COVID-19 severe patients severity subjects T cell T cell response T cells the patient uninfected vaccination [DOI] 10.1371/journal.ppat.1010211 PMC 바로가기 [Article Type] Research Article
Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen전혈 전사 반응의 뚜렷한 패턴은 동일한 항원을 암호화하는 아데노 바이러스 및 poxviral 벡터 백신으로 예방 접종 후 마우스에서 유도된다.Research Published on 2021-10-302022-09-10 Journal: BMC Genomics [Category] MERS, SARS, 유전자 메커니즘, [키워드] adaptive immune responses Adenovirus Administered Analysis Antigen antigens cell activation cellular ChAdOx1 change changes characterisation Combination combinations Comparative analysis COVID-19 vaccine Diseases effective Emerging infectious diseases Epigenetic evaluate Express expression Gene Expression gene signature Genes greater heterologous prime-boost human clinical trial human clinical trials humoral immune response immune responses Infectious diseases innate immune involved Killer cell leads magnitude mechanism MHC class I mice natural killer natural killer cell Pathogens pathway Protective protective response protective responses Rapid induction regimen Regulation response Result significant enrichment single dose supplementary material T cell These data TLR2 transcriptional transcriptional response transgene type I interferon type I interferon genes Vaccine vaccine construct vaccine platform valuable resource vector vectors Viral Viral vector vaccine was used Whole blood [DOI] 10.1186/s12864-021-08061-8 PMC 바로가기 [Article Type] Research
Immunogenicity of clinically relevant SARS-CoV-2 vaccines in nonhuman primates and humansReview Published on 2021-03-192022-10-04 Journal: Science Advances [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome antibody candidate clinical trials clinically coronavirus coronavirus disease doses Efficacy evaluated experiment Human humans immunized immunogenicity induce macaques Multiple NHP NHPs outcome pandemic performed Phase 3 protective response protocol Release resulting SARS-CoV-2 vaccine T cell the vaccine Trial trials Vaccine Variation virus [DOI] 10.1126/sciadv.abe8065 PMC 바로가기 [Article Type] Review
Viral Emerging Diseases: Challenges in Developing Vaccination StrategiesImmunology Published on 2020-09-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activate acute respiratory syndrome Antibody-dependent enhancement approach challenge conditions Coronavirus disease 2019 Coverage COVID-19 curtail Dengue Developing disease Ebola effective Emerging infectious diseases Epidemics example Fever fevers globe Health health emergency helping Hemorrhagic immune system imperative infections infectious virus Intervention Lassa fever MERS Middle East morbidity and mortality outbreak overcome Pandemics Pathogens protective response public health reducing SARS-CoV-2 Scientific community Spread Strategy swine flu syndrome the epidemic threat vaccination Vaccination strategy Vaccine Vaccine design Vaccines vector-borne diseases viruses West Nile fever yellow fever Zika zoonose [DOI] 10.3389/fimmu.2020.02130 PMC 바로가기 [Article Type] Immunology
Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the PastImmunology Published on 2020-08-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute phase against SARS-CoV antibody production association attack B cell caused classical clinical trial combating complexes component contagious convalescent plasma coronavirus coronavirus Coronaviruses correlated COVID-19 COVID-19 patients cross-reactivity cytokine cytokine secretion cytolytic develop disease disease severity downregulated drug expression flu Genome sequencing group help highlight HIV HLA Host identify IFNs IL-6 immune response Immunotherapy induce infected individual infected individuals Infection Influenza initiated interferon lesson limitation Local lymphopenia malaria memory memory T cell MERS MERS-CoV MHC MHC allele MHC alleles MHC presentation molecular neutralization neutralizing antibody Novel coronavirus nucleocapsid protein pandemic pathogenicity Plasma transfusion Pneumonia polymorphism populations preventive measures protective response Rapid recovered patient reported researcher Respiratory system response resulting SARS-CoV-2 similarity specific treatment Stage Symptom T cell epitope T cells T-cell TNF-α Treatment treatment strategy Tuberculosis Type Viral antigen viral infection Viremia virus virus particle [DOI] 10.3389/fimmu.2020.01949 PMC 바로가기 [Article Type] Immunology
Immunoinformatics and Structural Analysis for Identification of Immunodominant Epitopes in SARS-CoV-2 as Potential Vaccine TargetsArticle Published on 2020-06-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adaptive analysis antibody antigens approach B- and T-cell binding interaction caused Cell-mediated immunity complexes conserved contribute COVID-19 criteria defined effective epitope global pandemic HLA Host identification immunodominant immunodominant epitope Immunotherapy induce Infection international public health mapped MHC molecular docking New coronavirus Outbreaks pandemic peptide performed Potential predict predicted Prevent Protective protective response proteome provide reduce Region required SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein sequence significantly T-cell target Vaccine Vaccine design vaccine target [DOI] 10.3390/vaccines8020290 PMC 바로가기 [Article Type] Article
A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primatesArticle Published on 2015-09-042022-11-01 Journal: Science Translational Medicine [Category] Coronavirus, [키워드] acute respiratory syndrome antigen-specific neutralizing antibody antiviral therapy approved Arabian Peninsula cause caused cellular immunity characteristic Consensus coronavirus deaths disease DNA vaccine Europe exhibited increase in induce Infection lack Lineage macaque macaques MERS MERS coronavirus MERS spike protein MERS-CoV mice Middle East morbidity Mortality nosocomial pathogen Pneumonia Prevent protective immunity protective response Protein Radiographic respiratory syndrome coronavirus rhesus macaque route of infection SARS-CoV seroconverted syndrome The United States Transmission treat Vaccine viral challenge virus-neutralizing [DOI] 10.1126/scitranslmed.aac7462 PMC 바로가기 [Article Type] Article